Copper complexes as chemical nucleases
نویسندگان
چکیده
منابع مشابه
DNA oxidation profiles of copper phenanthrene chemical nucleases
The deleterious effects of metal-catalyzed reactive oxygen species (ROS) in biological systems can be seen in a wide variety of pathological conditions including cancer, cardiovascular disease, aging, and neurodegenerative disorder. On the other hand however, targeted ROS production in the vicinity of nucleic acids-as demonstrated by metal-activated bleomycin-has paved the way for ROS-active ch...
متن کاملChemical nucleases as probes for studying DNA-protein interactions.
Over the past fifteen years much research has been devoted to the mode(s) by which the linear DNA macromolecule communicates with cellular proteins in the course of genetic programming, thus determining the patterns of growth and development in living organisms. A plethora of proteins have been shown to interact non-covalently with DNA either as structural elements, exemplified by the histones ...
متن کاملAn effective approach to artificial nucleases using copper(II) complexes bearing nucleobases.
Novel copper(ii) complexes bearing 2,2'-bipyridine (bpy) derivatives with adenine, thymine and uracil nucleobases [Cu(L(1))Cl(2)].2H(2)O (1), [Cu(L(2))Cl(2)] (2) and [Cu(L(3))Cl(2)].H(2)O (3) (L(1) = 5,5'-Di[N9-adenylmethyl]-2,2'-bipyridine, L(2) = 5,5'-Di[N1-thyminylmethyl]-2,2'-bipyridine and L(3) = 5,5'-Di[N1-uracilmethyl]-2,2'-bipyridine) were synthesized and characterized. Structure simula...
متن کاملSynthesis, Characterization and Catalytic Activity of CuO Nanostructures using Schiff Base Copper Complexes as a Precursor
Two Cu(II) complexes, [Cu(L1)2](NO3)2 (1) and [Cu(L2)2] (NO3)2(2), which L1 and L2 Schiff base ligands are 2-(thiophene-2-yl) -1H-imidazo [4,5-f] [1,10] phenanthroline and 2-(furane-2-yl)-1H-imidazo[4,5-f] [1,10] phenenthroline, respectively, were syn...
متن کاملCopper N-heterocyclic carbene (NHC) complexes as carbene transfer reagents.
A method is described that makes use of easily prepared, inexpensive copper synthons as N-heterocyclic carbene (NHC) transfer agents to generate catalytically relevant gold and palladium complexes.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chemical Sciences
سال: 2002
ISSN: 0253-4134,0973-7103
DOI: 10.1007/bf02703829